autocamtide-2-related inhibitory peptide Myristoylated autocamtide-2-related inhibitory peptide acetate - auto-anticorps-anti-peptides-cycliques-citrullines-ccp2-positif is a CaM kinase II inhibitor Autocamtide-2-Related Inhibitory Peptide: A Potent Modulator of CaMKII Activity

autoimmune-peptides Autocamtide-2-related inhibitory peptide (AIP) stands as a significant tool in molecular biology and neuroscience research, primarily recognized for its role as a highly specific and potent inhibitor of calmodulin-dependent protein kinase II (CaMKII).Autocamtide-2-related inhibitory peptide (CAS 167114-91-2) This peptide has garnered considerable attention due to its ability to precisely control the biological activity of CaMKII, a crucial enzyme involved in a myriad of cellular processes, including synaptic plasticity, learning, and memory.

The efficacy of autocamtide-2-related inhibitory peptide lies in its remarkable selectivity. It functions as a selective and potent calmodulin-dependent protein kinase II (CaMKII) inhibitor with a reported IC50 of 40 nMAutocamtide-2-Related Inhibitory Peptide (AIP). This means that only a very small concentration of the peptide is required to inhibit half of the CaMKII activity.[Ala9]-Autocamtide-2is a highly potent and specific nonphosphorylatable inhibitor of calmodulin-dependent protein kinase II. MW: 1497.7. Crucially, autocamtide-2-related inhibitory peptide exhibits high specificity, meaning it does not significantly interfere with other important kinase families, such as cAMP-dependent protein kinase (PKA) or protein kinase C (PKC). This targeted action makes it an invaluable reagent for researchers seeking to elucidate the specific roles of CaMKII in various biological pathways without confounding effects from other signaling moleculesAutocamtide-2-related inhibitory peptide, myristoylatedis a CaM kinase II inhibitor; enhanced cell permeable derivative of Autocamtide-2-related inhibitory ....

Further enhancing its utility, a myristoylated autocamtide-2-related inhibitory peptide acetate derivative has been developed.Autocamtide-2 Related Inhibitory Peptide, Myristoylated The addition of a myristoyl group significantly improves the peptide's cell permeability, allowing for more effective delivery into cells and subsequent inhibition of intracellular CaMKII.作者：A Ishida·1998·被引用次数：77—We have recently demonstrated that a syntheticpeptide, designated as AIP, a nonphosphorylatable analog of apeptidesubstrate,autocamtide-2[5] ... This myristoylated autocamtide-2-related inhibitory peptide is therefore a powerful tool for studying CaMKII function in living cells and in vivo models. Research has demonstrated that myristoylated autocamtide-2-related inhibitory peptide can promote neuronal apoptosis by inhibiting CaMKII, highlighting its impact on cellular survival pathways.

The development of autocamtide-2-related inhibitory peptide is rooted in its design as a nonphosphorylatable analog of autocamtide-2. This strategic modification prevents the peptide itself from being phosphorylated, ensuring its inhibitory function remains consistent and is not subject to regulatory feedback mechanisms that might affect other inhibitory peptides. The autocamtide-2-related inhibitory peptide (AIP), as it is often abbreviated, is a small peptide with a molecular weight of approximately 1611This is a myristoylated form ofAutocamtide-2-Related Inhibitory Peptide(AIP), a highly potent and specific substrate competitive inhibitor of Calmodulin- ....76 Da, though variations like the myristoylated form have a higher molecular weight (e[Lys3, Phe10, Tyr13]-Autocamtide-2-Related Inhibitory ....g., 1708作者：A Ishida·1995·被引用次数：334—A novel synthetic peptide AIP (autocamtide-2-related inhibitory peptide), a nonphosphorylatable analog ofautocamtide-2, was found to be a highly specific and ....1 for C78H142N22O). The CAS Number for autocamtide-2-related inhibitory peptide is 167114-91-2.This is a myristoylated form ofAutocamtide-2-Related Inhibitory Peptide(AIP), a highly potent and specific substrate competitive inhibitor of Calmodulin- ...

The specificity of autocamtide-2-related inhibitory peptide is further underscored by studies investigating critical amino acid residues within its structure.Myristoylated autocamtide-2-related inhibitory peptide acetateis a cell-permeable CaM kinase II inhibitor. These investigations aim to refine its inhibitory properties and understand the precise molecular interactions that lead to potent CaMKII blockadeAutocamtide-2-related inhibitory peptide (AIP). For instance, modified versions like [Ala9]-Autocamtide-2 have also been explored, demonstrating the ongoing research into optimizing this class of inhibitors. Researchers can try our high quality amino acids, resins and reagents to explore custom peptide synthesis and modifications for advanced research applications.

In essence, autocamtide-2-related inhibitory peptide is a cornerstone in CaMKII research. Its ability to act as a highly specific and potent inhibitor of Ca2+/calmodulin-dependent protein kinase II and to control the biological activity of calmodulin-dependent protein kinase II makes it an indispensable tool for dissecting complex signaling cascades. Whether in its original form or as a cell-permeable myristoylated autocamtide-2-related inhibitory peptide, this peptide continues to facilitate significant advancements in our understanding of cellular regulation and neurological function. The availability of autocamtide-2-related inhibitory peptide as a high-purity protein kinase inhibitor ensures reliable and reproducible results in demanding scientific investigations.