human relaxin 2 peptide H2 relaxin is a peptide hormone - Relaxin-2peptidefor sale Relaxin-2 is a peptide hormone structurally related to insulin Understanding Human Relaxin-2 Peptide: A Multifaceted Hormone

Relaxin-2peptidefor sale The human relaxin-2 peptide, also known as H2 relaxin, is a captivating peptide hormone with a significant role in various physiological processesRelaxin 2 (Human) - 20µg. Structurally related to insulin, this peptide hormone belongs to the larger human relaxin peptide family, which comprises seven cystine-rich peptides. The gene encoding human relaxin-2 is mapped to human chromosome 9p24, and it is notably expressed in the placenta, decidua, prostate, and the ovary during pregnancyRecombinant Human Relaxin-2, AMS.32-4663.

The Structure and Characteristics of Human Relaxin-2

Human Relaxin-2 is a 6 kDa polypeptide hormone, typically consisting of 53 amino acids. It is a heterodimeric protein, formed by an A-chain of 24 amino acids and a B-chain of 29 amino acids, linked together by two disulfide bondsRelaxin is an ovarian hormone that acts with estrogento produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective .... This intricate structure is crucial for its biological activity.Therelaxinfamilypeptidehormones belong to the insulin superfamily and consists of sevenpeptidesof high structural but low sequence similarity;relaxin-1 ( ... The NMR structure of a monomeric, amidated form of H2 relaxin has been elucidated, providing deeper insights into its conformational properties and behavior in solution compared to its native formRelaxin 2 (RLN2) also known as human relaxinis a peptide hormone with a molecular mass of approximately 6 kDa. It belongs to the insulin superfamily. This .... While the native human relaxin-2 is a disulfide-linked heterodimer, researchers have also synthesized and studied truncated or modified versions, such as the A-chain truncated human relaxin-2 and -3 (H2 and H3) relaxin peptides, to understand structure-activity relationships.

Physiological Roles and Therapeutic Potential

Relaxin is an ovarian hormone that works in conjunction with estrogen. A key function attributed to relaxin is its role in the dilation of the birth canal in many mammals, a vital aspect of reproduction. Beyond its reproductive functions, human relaxin-2 mediates a range of pleiotropic cardiovascular effects. These include antifibrotic, angiogenic, and vasodilatory properties, as well as antiapoptotic effects.重组人Relaxin 2/RLN2蛋白(His tag) Its ability to regulate collagen metabolism is also a significant area of research.

The therapeutic potential of human relaxin-2 is being actively explored. It is currently in clinical trials with our commercial partner BAS Medical for treating conditions such as congestive heart failure, cervical ripening, and preeclampsia. The peptide hormone relaxin: from bench to bedside narrative highlights the ongoing efforts to translate its physiological understanding into clinical applications. Researchers are investigating various forms, including Recombinant Human Relaxin-2, to harness its therapeutic benefits.作者：J Sun·2019·被引用次数：34—Relaxin‐2 is a peptide hormonethat mediates pleiotropic cardiovascular effects, including antifibrotic, angiogenic, vasodilatory, antiapoptotic ... For instance, some studies suggest that Relaxin in paraventricular nucleus contributes to sympathetic overdrive and hypertension via PI3K-Akt pathway, indicating its involvement in cardiovascular regulationEverything we know about the human relaxin peptide family. Furthermore, H2 and H3 relaxin inhibit high glucose-induced effects, hinting at potential applications in metabolic disorders.Human Relaxin‐2 Fusion Protein Treatment Prevents and ...

Availability and Research

For those involved in scientific research, Relaxin-2 peptide for sale is available from various sources, with companies like Peptide Institute, Inc.Relaxin-2 is a peptide hormone structurally related to insulin. The gene is mapped to human chromosome 9p24. It is expressed in the placenta, decidua, ... being a global supplier of Relaxin-2 (Human). These suppliers offer Recombinant Human Relaxin-2 in different forms, such as RLN2 protein solution (1mg/ml), and specific quantities like 20µg or 250 µg. Researchers also utilize specialized kits, such as the Human Relaxin-2 Quantikine ELISA Kit (DRL200) or the Human Relaxin 2 (RLN2) ELISA Kit, for quantitative analysis. The availability of these resources facilitates further investigation into the complex roles of human relaxin-2 in both health and disease. The broader relaxin family, including Relaxin-3, also continues to be a subject of scientific inquiry.